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The fnancial statements on pages 78 to a hundred and five had been authorised for issue by the Board of Directors on 26 February 2015 and had been signed on its behalf by Steven Harris Julien Cotta Chief Executive Ofcer Chief Financial Ofcer Circassia Pharmaceuticals plc Circassia Pharmaceuticals plc Registered quantity: 05822706 Circassia Pharmaceuticals plc Annual report and accounts 2014 eighty Group and parent Company assertion of money fows For the 12 months ended 31 December 2014 Group Company 2014 2013 2014 2013 Notes £’000 £’000 £’000 £’000 Cash fows from operating actions Cash utilized in operations 26 (forty one, 010) (22, 168) (28, 695) (6, 199) Interest acquired 246 1, 279 206 366 Interest paid (15) (11) (7) – Tax credit score acquired four, 052 3, 019 – – Net cash used in operating actions (36, 727) (17, 881) (28, 496) (5, 833) Cash fows from investing actions Investment in subsidiary – – (6) – Purchases of intangibles (38) – – – Purchases of property, plant & tools (333) – – – (Increase)/lower in brief-time period bank deposits (149, 827) 27, 179 (149, 827) four, 184 Net cash (used in)/from investing activities (a hundred and fifty, 198) 27, 179 (149, 833) 4, 184 Cash fows from fnancing actions Proceeds from issue of Ordinary shares 192, 574 2 192, 574 2 Net money from fnancing actions 192, 574 2 192, 574 2 Net increase/(lower) in money and cash equivalents 5, 649 9, 300 14, 245 (1, 647) Cash and money equivalents 1 January 16 23, 568 13, 981 3, 839 5, 621 Exchange features/(losses) on cash and money equivalents 499 287 670 (135) Cash and cash equivalents at 31 December sixteen 29, 716 23, 568 18, 754 three, 839 the notes on pages 84 to a hundred and five are an integral part of these consolidated fnancial statements. 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Risk components embrace the fol lowing: • Fair complexion, blue eyes, pink or blond hair, and freckles • Celtic or Scandinavian origin • Tendency to burn and not tan; signi?cant historical past of severe sunburn • Older age; residence in the southwestern United States • Family or private historical past of melanoma, the absence of a gene on chromosome 9P, presence of giant congenital nevi • Dysplastic nevus syndrome Clinical Manifestations Super?cial Spreading Melanoma • Most common kind; often impacts middle-aged people, occurs most frequently on trunk and decrease extremities • Circular lesions with irregular outer portions • Margins of lesion ?at or elevated and palpable • May seem in combination of colors, with hues of tan, brown, and black mixed with grey, bluish black, or white; sometimes a boring, pink-rose shade is noted in a small area throughout the lesion Lentigo-Maligna Melanoma • Slowly evolving pigmented lesion • Occurs on uncovered pores and skin areas; hand, head, and neck in eld erly individuals • First seems as tan, ?at lesion, which in time undergoes modifications in dimension and colour Nodular Melanoma • Spherical, blueberrylike nodule with comparatively clean sur face and uniform blue-black shade Cancer of the Skin (Malignant Melanoma) 193 • May be dome-shaped with a smooth surface or produce other shadings of red, gray, or purple • May appear as irregularly shaped plaques C • May be described as a blood blister that fails to resolve • Invades immediately into adjoining dermis (vertical development); poor prognosis Acral-Lentiginous Melanoma • Occurs in areas not excessively exposed to sunlight and the place hair follicles are absent • Found on the palms of the hands, soles, in nail beds, and mucous membranes in dark-skinned people • Appears as an irregular pigmented macule that develops nodules • Becomes invasive early Assessment and Diagnostic Methods • Excisional biopsy specimen; incisional biopsy when the sus picious lesion is too large to be eliminated safely without in depth scarring. 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