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In some embodiments, the non-naturally occurring microbial organism additional includes a 1,3-butanediol pathway comprising at least one exogenous nucleic acid encoding an enzyme chosen from: 1) Hydrogenase, 2) Carbon monoxide dehydrogenase, 3) Succinyl-CoA transferase, or Succinyl-CoA synthetase (or succinyl-CoA ligase), 4) Succinyl-CoA reductase (aldehyde forming), 5) 4-Hydroxybutyrate dehydrogenase, 6) four-Hydroxybutyrate kinase, 7) Phosphotrans-four-hydroxybutyrylase, eight) 4-Hydroxybutyryl-CoA dehydratase, 9) Crotonase, 10) 3-Hydroxybutyryl-CoA reductase (aldehyde forming), 11) 3-Hydroxybutyraldehyde reductase, 12) Succinate reductase, thirteen) Succinyl-CoA reductase (alcohol forming), 14) 4-Hydroxybutyryl-CoA transferase, or four-Hydroxybutyryl-CoA synthetase, 15) three-Hydroxybutyryl-CoA reductase (alcohol forming), 16) three-Hydroxybutyryl-CoA hydrolase, or three-Hydroxybutyryl-CoA synthetase, or 3-Hydroxybutyryl-CoA transferase, 17) three-Hydroxybutyrate reductase In some embodiments, the non-naturally occurring microbial organism includes a butanol pathway that includes no less than one exogenous nucleic acid encoding an enzyme chosen from 1) Hydrogenase, 2) Carbon monoxide dehydrogenase, three) Succinyl-CoA transferase, or Succinyl-CoA synthetase (or succinyl-CoA ligase), 4) Succinyl-CoA reductase (aldehyde forming), 5) four-Hydroxybutyrate dehydrogenase, 6) four-Hydroxybutyrate kinase, 7) Phosphotrans-four-hydroxybutyrylase, 8) four-Hydroxybutyryl-CoA dehydratase, 9) butyryl-CoA dehydrogenase, 10) Butyryl-CoA reductase (aldehyde forming), 11) Butyraldehyde reductase, 12) Succinate reductase, thirteen) Succinyl-CoA reductase (alcohol forming), 14) four-Hydroxybutyryl-CoA transferase, or four-Hydroxybutyryl-CoA synthetase, 15) Butyryl-CoA reductase (alcohol forming), 16) Butyryl-CoA hydrolase, or Butyryl-CoA synthetase, or Butyryl-CoA transferase, 17) Butyrate reductase. 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