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Clinical research on pyridoxine in relation to neurological effects (see Table 2 for particular person/anecdotal evidence) Duration Dosage Authors Subjects Number of Findings Conclusions (mg/day) treatment No changes in distal Patients with motor Duration too Del Tredici et al carpal tunnel 24 one hundred fifty or 300 4 months latency or quick to evaluate (1985) syndrome self-assesneurological effects sment questionnairethe situation may be because of pyridoxine de Ellis et al Patients with No opposed ciency; typical treatment (1979) (and carpal tunnel 35 a hundred-300 as much as 12 neurologischedule of 12 weeks research cited); syndrome weeks cal results (Ellis, 1987) is of too quick Ellis (1987) reported length to access neurological results Patients with No assessDuration too Kerr (1977) premenstrual 70 40-a hundred 2 months ment of side short to evaluate syndrome effects neurological results No neurological comSmall group measurement however plications in very extended length; Patients with 22 sufferers inuence of the or nerve Mitwalli et al hyperoxaluria 22 250-500 1-6 years conduction disease on (1984) (kidney abnormapyridoxine dealing with, stones) necessities and lities in 7 sufferers neurological response aren't recognized studied in detail Small group size however very No abnorextended duration; the malities of absence of effects at Patients with motor or doses equal to 10-90 Mpofu et al homocystei17 200-500 10-24 years sensory mg/kg/day suggests that (1991) nuria nerve these sufferers might show conduction lowered responsiveness velocities to the neuronal antagonistic results of pyridoxine Pauling (1984) Undened >5000 200 not given No particulars No particulars obtainable; cites Hawkins patients cannot be assessed No assesResults from a survey Pullon et al Women 410 not described not described sments of of 1826 girls; no (1989) possible data on tolerability neuropathy and unwanted effects No effects Small variety of subjects and very limited Tolis et al Women 9 200 or four hundred 2 months on development duration of therapy; (1977) hormone or no assessment of prolactin neurological results No distinction in Women with side effects Duration too Williams et al premenstrual 204 (out a hundred 3 months between brief to entry (1985) syndrome of 434) therapies neurological results and placebo teams Data assessment for A systematic review of revealed and Women with reviews of unpublished Wyatt et al premenstrual 526 (out 50-600 as much as four unwanted side effects; randomised (1999) syndrome of 910) months 1 reported placebo managed case of trials; all research of neurological inadequate period unwanted side effects 37 europa. 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