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Gnaremolley
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OsmundThitygata
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AldoAmets
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Fasimnah
Fasimnah
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Chapter 2 First trimester abortion 17 Table 5: Mode of motion of medicine used for medical abortion, and their side-results Drugs Action Side-effects Mifepristone • An anti-progestin that blocks the endometrial • Nausea, vomiting, diarrhoea, headache, dizziness, fatigue, progesterone receptors tachycardia • Stops the pregnancy growing, softens the cervix, increases the uterine contractility, causes bleeding Misoprostol • A prostaglandin that makes the uterus contract • Cramping (more pain than menstrual ache in 25% of sufferers), nausea, vomiting, diarrhoea, transient fever, dizziness, headache, chills, rashes Methotrexate • A folic acid antagonist that stops cellular division • Mild mouth sores, nausea, vomiting, gastro-intestinal • Halts placental growth disturbances, hot flushes, fever, chills Gemeprost • A prostaglandin that makes the uterus contract • Nausea, vomiting, diarrhoea, transient fever, belly pain Table 6: Regimens for medical abortion and their effectiveness Regimens Effectiveness Use up to Mifepristone + misoprostol or >ninety six% 9 weeks from last menstrual period mifepristone + gemeprost Misoprostol alone >eighty three% 12 weeks from last menstrual period Methotrexate + misoprostol >90% 9 weeks from last menstrual interval • Porphyria. 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