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Incidences of selected neoplastic histologic modifications in male and female Sprague-Dawley rats uncovered to dichloromethane by inhalation (6 hours/day, 5 days/week) for two years a Exposure (ppm) 0 Late Early b b Lesion, by sex (Controls) 50 200 500 500 500 MalesпїЅn per group 70 70 70 70 zero zero Number (%) with: c Liver tumors 0 (0) 0 (zero) zero (0) 0 (zero) c Lung tumors 0 (zero) 0 (zero) zero (0) zero (zero) c Mammary gland tumors Adenocarcinoma or carcinoma zero (0) 0 (0) 0 (0) zero (zero) Fibroadenoma 2 (four) zero (0) 2 (three) 2 (3) Fibroma 6 (eleven) 1 (6) 6 (11) 10 (sixteen) Fibrosarcoma 0 (0) 1 (6) 1 (6) 0 (zero) Undifferentiated sarcoma 0 (zero) 2 (4) zero (zero) zero (zero) d Fibroma, fibrosarcoma, or undifferentiated sarcoma 6 (eleven) 4 (6) 7 (12) 10 (16) c Brain tumors Astrocytoma or glial cell 0 (zero) 1 (1) 2 (3) 1 (1) Granular cell 0 (0) 0 (0) zero (0) 1 (1) FemalesпїЅn per group 70 70 70 70 25 25 Number (%)with: c Liver tumors Neoplastic nodule(s) four (6) four (6) three (4) 4 (6) zero (0) 1 (four) Hepatocellular carcinoma 1 (1) 0 (zero) 2 (3) 1 (1) 0 (0) 0 (0) c Lung tumors zero (zero) zero (0) 0 (zero) 0 (zero) zero (zero) 0 (0) c Mammary gland tumors Adenocarcinoma or carcinoma 4 (6) 5 (7) 4 (6) 3 (4) three (12) 2 (eight) Adenoma 1 (1) 1 (1) 2 (3) 1 (1) 2 (eight) zero (zero) Fibroadenoma 51 (seventy four) fifty seven (83) 60 (87) fifty five (80) 22 (88) 23 (ninety two) Fibroma 0 (0) 1 (1) zero (0) 1 (1) 1 (4) 0 (0) Fibrosarcoma 1 (1) 0 (zero) zero (zero) zero (0) zero (zero) 0 (zero) Number with palpable plenty in subcutaneous or 55 (seventy nine) 56 (eighty) 60 (86) fifty nine (84) 22 (88) 23 (92) mammary area e e e Number of palpable plenty in subcutaneous or 1. 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