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Drugs utilized in Endocrine Disorders and Contraceptives 311 sickle-cell disease; inflammatory bowel illness including crohn disease; see additionally interactions Drug interactions: see notes above Contraindications: pregnancy; twenty-one days postpartum; breastfeeding till weaning or for first 6 months postpartum; private history of venous or arterial thrombosis, heart disease associated with pulmonary hypertension or danger of embolism; migraine; history of sub-acute bacterial endocarditis; ischaemic cerebrovascular disease; liver disease, together with issues of hepatic secretion such as Dubin Johnson or Rotor syndromes, infections hepatitis (until liver function regular); porphyria; systemic lupus erythematosus; liver adenoma; historical past of cholestasis; gall stones: estrogen dependent neoplasms; neoplasms of breast or genital tract; undiagnosed vaginal bleeding; historical past throughout pregnancy of pruritus, chorea, herpes, deteriorating otosclerosis; cholestatic jaundice; pemphigoid gestationis; diabetes mellitus (if both retinopathy, neuropathy or if greater than 20 years length); after evacuation of hydatidiform mole (till return to regular of urine and plasma gonadotrophin values) Side results: nausea, vomiting, headache, breast tenderness, increase in body weight, thrombosis, modifications in libido, depression, chorea, pores and skin response, chloasma, hypertension, impairment of liver operate, 'recognizing' in early cycles, absence of withdrawal bleeding, irritation of contact lenses; not often, photosensitivity and hepatic tumours; breast cancer (small increase in danger of breast most cancers throughout use which reduces in the course of the 10 years after stopping; danger factor appears associated to age at which contraceptive is stopped quite than total duration of use; small increase in risk of breast cancer should be weighed towards the protecting effect of the ovary and endometrium) Dose and Administrations Contraception (21 day mixed (monophasic) preparations), by mouth, Adult (female), 1 tablet ('capsule') daily for 21 days; subsequent programs repeated after 7 day capsule free interval (during which withdrawal bleeding happens) Administration each pill (capsule') must be taken at roughly the same time each day; if delayed by longer than 24 hours contraceptive protection may be lost. 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