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Cells are starting to break via the basement membrane Uniform basal nuclei in orderly cuboidal cells Pancreatic A denocarcinom a Clinical Features O ften rem ains silent until it im pinges on som e other structure Pancreatic cancers prefer to invade nerves Pain is usually one of the first sym ptom s Due to increased O bstructive jaundice is com m on bilirubin W eight loss, anorexia, generalized m alaise and w eakness D isease course is usually temporary and progressive Few er than 20% are resectable on the tim e of analysis Pancreatic Cancer M acroscopic Features 60% happen within the H O P 15% body Head of the 5% tail Pancreas 20% diffusely includes the pancreas G ross exam: H ard, stellate, grayw hite, poorly defined Carcinom a in the H O P typically leads to obstruction Carcinom a of the body and tail m ay rem ain silent for an extended period of tim e Infiltrative nature typically results in extension into retroperitoneal house and lym phovascular invasion M etastasis to liver is And to the supraclavicular nodes on the left com m on facet and the periumbilical area (Goljan) M icroscopic Findings D uctal adenocarcinom as recapitulate to som e degree the norm al ductal epithelium by form ing glands and secreting m ucin 2 features highly characteristic of pancreatic ductal adenocarcinom a H ighly infiltrative Elicits an intense nonneoplastic host response com prised of fibroblasts, chronic inflam m atory cells, and m atrix desm oplastic response Possible examination query <a href=http://usacareerguides.com/training/buy-cheap-rumalaya-liniment/> muscle relaxant hydrochloride purchase 60ml rumalaya liniment otc</a>. 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