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All Exp Med Surg Exp Proc Surg Exp Surg Studies (N) 14 27 2 1 18 9 1 25 ninety seven a Location North America 8 9 zero 1 7 0 0 zero 25 Europe 5 11 2 0 four 7 1 15 forty five Asia zero three zero zero 7 2 0 8 20 Middle East 1 four zero zero 0 zero zero 1 6 South America zero 0 0 0 zero 0 0 1 1 Decade of 1985 to1995 2 6 1 zero 0 zero 0 zero 9 Publication 1996 to 2005 5 eight 1 0 3 2 zero 10 29 2006 to 2016 7 13 0 1 15 7 1 15 fifty nine Study Quality Good 2 2 0 zero four 2 zero 8 18 Fair 5 7 0 1 four three zero 7 27 Poor 7 18 2 zero 10 4 1 10 fifty two Participants Randomized 1,159 2,570 114 20 1,171 962 181 3,002 9,179 Note: None of the included research compared medicine with procedure or process with expectant administration Exp = expectant administration; Med = medical; N = number; Proc = procedural; Surg = surgical aIncludes studies performed within the United States, Canada, and Cuba. 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