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Mendelian Inheritance the patterns of inheritance proven by single-gene disorders in families rely chiefly on two components: • Whether the chromosomal location of the gene locus is on an autosome (chromosomes 1 to 22), on a intercourse chromosome (X and Y chromosomes), or in the mitochondrial genome • Whether the phenotype is dominant (expressed when only one chromosome carries the mutant allele) or recessive (expressed only when each chromosomes of a pair carry mutant alleles at a locus) Autosomal, X-Linked, and Mitochondrial Inheritance the totally different patterns of transmission of the autosomes, intercourse chromosomes, and mitochondria during meiosis end in distinctive inheritance patterns of mutant alleles on these different types of chromosome (see Chapter 2). These situations usually require surgical treatthe patient on unfractionated heparin could have regular ment throughout childhood to permit survival. 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Susan Webb Yackee Assistant Professor of Public Affairs and Political Science May 2010 v Acknowledgments We would like to thank the following people for his or her contributions in the prepa ration of this report: Eric Pearson, City of Milwaukee Budget Office Budget and Policy Manager for his steerage; Ghassan Korban, City of Milwaukee Depart ment of Public Works Coordinator Manager; and Jeff Polenske, City of Milwau kee Department of Public Works City Engineer, for his or her constructive feedback; the various municipal employees who took time to respond to survey questions about their development mitigation programs; the varied other people who provided information about development mitigation providers; Karen Faster for her modifying and comments; and to Susan Yackee for her guidance and support all through this project. At each visit, any adverse signs are care to display circumstances for contraindications (headache, to be noted. 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