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<p class="mol-para-with-font">The defending champions are on the ropes, and the best team in the NHL has another chance to move on to the second round of the playoffs.</p> <p class="mol-para-with-font">All four <a rel="nofollow noreferrer noopener" target="_blank" website series</a> resuming Friday night feature a Game 6 with potential elimination. The most surprising team on the brink is Colorado, <a rel="nofollow noreferrer noopener" target="_blank" website 3-2 to the Kraken</a> with the series going back to Seattle.</p> <p class="mol-para-with-font">There are a pair of second chances in the East, with top-seeded Boston trying to put away Florida and Carolina looking to advance past the New York Islanders. <a href=https://v2t0r.com>vk2 at</a> Out West, <a rel="nofollow noreferrer noopener" target="_blank" website is on the verge</a> of knocking off Minnesota and moving on.</p> <p class="mol-para-with-font">All eyes now are on the Avalanche, who are one loss away from being the first reigning Stanley Cup champion to lose to a team making its first playoff appearance in franchise history.</p> <p class="mol-para-with-font">"With the culture we have here, belief is the biggest thing and that?s instilled from the top down, so that?s never going to go away," veteran forward Andrew Cogliano said Thursday. "But I think we?re at a point now where action is much louder than words."</p> <p class="mol-para-with-font">It's time for action from the Bruins, too, after they missed their first chance to move past the Panthers, with <a rel="nofollow noreferrer noopener" target="_blank" website overtime loss Wednesday</a> punctuated by uncharacteristic mistakes. As captain Patrice Bergeron said afterward, he and his teammates can't give an opportunistic opponent "freebies" as they did in Game 5 at home.</p> <div class="artSplitter mol-img-group"> <div> <div class="image-wrap"> <img id="i-dba3530b4dcce34b" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" website height="384" width="634" alt="Seattle Kraken defenseman Carson Soucy, left, celebrates with center Yanni Gourde, who scored against the Colorado Avalanche during the third period of Game 5 of an NHL hockey first-round playoff series Wednesday, April 26, 2023, in Denver. (AP Photo/David Zalubowski)" class="blkBorder img-share" style="max-width:100%" /> </div> <noscript> <img id="i-dba3530b4dcce34b" website height="384" width="634" alt="Seattle Kraken defenseman Carson Soucy, left, celebrates with center Yanni Gourde, who scored against the Colorado Avalanche during the third period of Game 5 of an NHL hockey first-round playoff series Wednesday, April 26, 2023, in Denver. (AP Photo/David Zalubowski)" class="blkBorder img-share" /> </noscript> </div> <p class="imageCaption mol-para-with-font">Seattle Kraken defenseman Carson Soucy, left, celebrates with center Yanni Gourde, who scored against the Colorado Avalanche during the third period of Game 5 of an NHL hockey first-round playoff series Wednesday, April 26, 2023, in Denver. (AP Photo/David Zalubowski)</p> </div> <p class="mol-para-with-font">Game 6 is on the road at Florida, and the Bruins still have the series lead looking to be the 10th Presidents' Trophy winners in the past 11 years to win at least one series.</p> <p class="mol-para-with-font">"I?m sure we?re going to come back with a real good, determined effort," Boston coach Jim Montgomery said. "I have a lot of confidence in our team."</p> <p class="mol-para-with-font">Confidence isn't lacking for the Avalanche, either, especially after their Cup run a year ago. They'll also get a boost with the return of 2022 playoff MVP Cale Makar from a one-game suspension.</p> <p class="mol-para-with-font">But much like Boston, the pressure is on Colorado.</p> <p class="mol-para-with-font">"They?re playing loose, they?re confident," coach Jared Bednar said of the Kraken. "Obviously the guys in their room are like, `Yeah, we want to win,? but expectations are on our team."</p> <p class="mol-para-with-font">HURRICANES at ISLANDERS, Carolina leads 3-2 (7 p.m. EDT, TBS)</p> <p class="mol-para-with-font">The Hurricanes lost <a rel="nofollow noreferrer noopener" target="_blank" website 5 at home</a> despite outshooting the Islanders 36-22 and dictating for long stretches. Two Islanders goals came off Carolina turnovers, and the <a rel="nofollow noreferrer noopener" target="_blank" website banked off Hurricanes star Sebastian Aho's face</a> for another.</p> <p class="mol-para-with-font">Otherwise, it might've been the team's best 5-on-5 game of the series.</p> <p class="mol-para-with-font">"You feel like you played good enough to win, but the bounces didn?t quite go our way," Hurricanes forward Seth Jarvis said. "But for us, even watching video you could tell, we played the way we want to play."</p> <p class="mol-para-with-font"><a rel="nofollow noreferrer noopener" target="_blank" website Jack Drury is out again</a> after being knocked out of Game 4 on a hard hit into the boards, according to coach Rod Brind'Amour, who didn't rule out the possibility of going with Frederik Andersen in net after Antti Raanta started the first five games.</p> <p class="mol-para-with-font">There are no questions about Ilya Sorokin being back in net for the Islanders after he made 34 saves to help New York win its first elimination game. Now comes another, this one with home-ice advantage and the chance to push the series to a Game 7 in Raleigh.</p> <p class="mol-para-with-font">BRUINS at PANTHERS, Boston leads 3-2 (7:30 p.m., TNT)</p> <p class="mol-para-with-font">The word that Florida coach Paul Maurice keeps using is freedom.</p> <p class="mol-para-with-font">Yes, there?s an obvious pressure when facing elimination - which the Panthers were in Game 5 in Boston before winning 4-3 - but there's also much less from the outside going against the team that had the best regular season in NHL history.</p> <p class="mol-para-with-font">"These are hard games for these guys to play," Maurice said. "You just have to mentally process one, and fight, and that brings that freedom. That?s the exact word I used before that game. You want to play with a freedom."</p> <p class="mol-para-with-font">Sergei Bobrovsky looked like his best self, and a stop on a breakaway in the final second of regulation got Florida to overtime - on a night the Bruins outshot the NHL?s most-prolific shooting team in the regular season 47-25.</p> <p class="mol-para-with-font">"The veteran players and also your highest-paid players, these are the games where the pressure has to be on their shoulders, and they have to rise to the occasion," Maurice said. "And he did. Everything that we could have hoped for from Sergei, he delivered."</p> <p class="mol-para-with-font">The Panthers have not won two elimination games in the same series, or the same playoffs, since 1996. They may or may not have Ryan Lomberg for their latest attempt, with Maurice calling the forward a game-time decision.</p> <p class="mol-para-with-font">STARS at WILD, Dallas leads 3-2 (9:30 p.m., TBS)</p> <p class="mol-para-with-font">Joe Pavelski could return for the Stars in their first chance to advance after missing the past four games in concussion protocol from a hit from Minnesota's Matt Dumba in the series opener.</p> <p class="mol-para-with-font">Coach Peter DeBoer said Pavelski, at 38 the second-oldest player in the playoffs and a key leader for Dallas, was traveling to the Twin Cities after just about a full practice.</p> <p class="mol-para-with-font">The Stars have survived so far without Pavelski, thanks to the production of center <a rel="nofollow noreferrer noopener" target="_blank" website Hintz, the leading scorer in the first round</a> with 11 points, and goaltender Jake Oettinger, who stopped all 27 shots he faced Tuesday in Game 5 for the first shutout of this postseason.</p> <p class="mol-para-with-font">Another win <a rel="nofollow noreferrer noopener" target="_blank" website his home state</a> would vault the Stars into the second round and a matchup against either Colorado or Seattle.</p> <p class="mol-para-with-font">"We have a great opportunity ahead of us," said Oettinger, who has a .925 save percentage so far. "This is exactly where we want to be."</p> <p class="mol-para-with-font">AVALANCHE AT KRAKEN, Seattle leads 3-2 (10 p.m., TNT)</p> <p class="mol-para-with-font">The Kraken are trying to treat the moment just as if it's any other situation. But players and coach Dave Hakstol know the gravity of the situation.</p> <p class="mol-para-with-font">"We know what?s on the line, believe me," Hakstol said. "We want to go home and play well and get the job done at home."</p> <p class="mol-para-with-font">The Kraken have put Nathan MacKinnon and the high-flying Avalanche on their heels by scoring first in all five games. The Avalanche would like to reverse that trend and send the series back to Denver for a Game 7 Sunday.</p> <p class="mol-para-with-font">"We?ve got to have some desperation ... and just find a way," forward Mikko Rantanen said.</p> <p class="mol-para-with-font">___</p> <p class="mol-para-with-font">AP Sports Writers Pat Graham, Tim Reynolds, Aaron Beard, Jimmy Golen, Stephen Hawkins and Dave Campbell contributed.</p> <p class="mol-para-with-font">___</p> <p class="mol-para-with-font">AP NHL playoffs: <a rel="nofollow noreferrer noopener" target="_blank" website and <a rel="nofollow noreferrer noopener" target="_blank" website <div class="artSplitter mol-img-group"> <div> <div class="image-wrap"> <img id="i-da78230b4eaab3ed" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" website height="427" width="634" alt="Colorado Avalanche goaltender Alexandar Georgiev reacts after giving up a goal to Seattle Kraken center Morgan Geekie during the second period of Game 5 of an NHL hockey first-round playoff series Wednesday, April 26, 2023, in Denver. (AP Photo/David Zalubowski)" class="blkBorder img-share" style="max-width:100%" /> </div> <noscript> <img id="i-da78230b4eaab3ed" website height="427" width="634" alt="Colorado Avalanche goaltender Alexandar Georgiev reacts after giving up a goal to Seattle Kraken center Morgan Geekie during the second period of Game 5 of an NHL hockey first-round playoff series Wednesday, April 26, 2023, in Denver. (AP Photo/David Zalubowski)" class="blkBorder img-share" /> </noscript> </div> <p class="imageCaption mol-para-with-font">Colorado Avalanche goaltender Alexandar Georgiev reacts after giving up a goal to Seattle Kraken center Morgan Geekie during the second period of Game 5 of an NHL hockey first-round playoff series Wednesday, April 26, 2023, in Denver. (AP Photo/David Zalubowski)</p> </div> <div class="artSplitter mol-img-group"> <div> <div class="image-wrap"> <img id="i-da782303c843e422" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" website height="422" width="634" alt="Boston Bruins head coach Jim Montgomery watches from the bench during the third period of Game 5 in the first round of the NHL hockey playoffs, Wednesday, April 26, 2023, in Boston. (AP Photo/Charles Krupa)" class="blkBorder img-share" style="max-width:100%" /> </div> <noscript> <img id="i-da782303c843e422" website height="422" width="634" alt="Boston Bruins head coach Jim Montgomery watches from the bench during the third period of Game 5 in the first round of the NHL hockey playoffs, Wednesday, April 26, 2023, in Boston. (AP Photo/Charles Krupa)" class="blkBorder img-share" /> </noscript> </div> <p class="imageCaption mol-para-with-font">Boston Bruins head coach Jim Montgomery watches from the bench during the third period of Game 5 in the first round of the NHL hockey playoffs, Wednesday, April 26, 2023, in Boston. (AP Photo/Charles Krupa)</p> </div> <div class="artSplitter mol-img-group"> <div> <div class="image-wrap"> <img id="i-dba3530968be701e" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" website height="422" width="634" alt="Florida Panthers left wing Matthew Tkachuk (19) leaps on goaltender Sergei Bobrovsky (72) while celebrating after scoring the game-winning goal against the Boston Bruins during overtime of Game 5 in the first round of the NHL hockey playoffs, Wednesday, April 26, 2023, in Boston. (AP Photo/Charles Krupa)" class="blkBorder img-share" style="max-width:100%" /> </div> <noscript> <img id="i-dba3530968be701e" website height="422" width="634" alt="Florida Panthers left wing Matthew Tkachuk (19) leaps on goaltender Sergei Bobrovsky (72) while celebrating after scoring the game-winning goal against the Boston Bruins during overtime of Game 5 in the first round of the NHL hockey playoffs, Wednesday, April 26, 2023, in Boston. (AP Photo/Charles Krupa)" class="blkBorder img-share" /> </noscript> </div> <p class="imageCaption mol-para-with-font">Florida Panthers left wing Matthew Tkachuk (19) leaps on goaltender Sergei Bobrovsky (72) while celebrating after scoring the game-winning goal against the Boston Bruins during overtime of Game 5 in the first round of the NHL hockey playoffs, Wednesday, April 26, 2023, in Boston. (AP Photo/Charles Krupa)</p> </div> <div class="artSplitter mol-img-group"> <div> <div class="image-wrap"> <img id="i-dba35303c811655b" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" website height="422" width="634" alt="Carolina Hurricanes' Stefan Noesen skates on the ice following the Hurricanes' loss to the New York Islanders in Game 5 of an NHL hockey Stanley Cup first-round playoff series in Raleigh, N.C., Tuesday, April 25, 2023. (AP Photo/Karl B DeBlaker)" class="blkBorder img-share" style="max-width:100%" /> </div> <noscript> <img id="i-dba35303c811655b" website height="422" width="634" alt="Carolina Hurricanes' Stefan Noesen skates on the ice following the Hurricanes' loss to the New York Islanders in Game 5 of an NHL hockey Stanley Cup first-round playoff series in Raleigh, N.C., Tuesday, April 25, 2023. (AP Photo/Karl B DeBlaker)" class="blkBorder img-share" /> </noscript> </div> <p class="imageCaption mol-para-with-font">Carolina Hurricanes' Stefan Noesen skates on the ice following the Hurricanes' loss to the New York Islanders in Game 5 of an NHL hockey Stanley Cup first-round playoff series in Raleigh, N.C., Tuesday, April 25, 2023. (AP Photo/Karl B DeBlaker)</p> </div> <div class="artSplitter mol-img-group"> <div> <div class="image-wrap"> <img id="i-da78230f0f45b3ed" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" website height="422" width="634" alt="Carolina Hurricanes goaltender Antti Raanta (32) jumps up to block a shot of the New York Islanders with Jean-Gabriel Pageau (44) close by during the third period of Game 5 of an NHL hockey Stanley Cup first-round playoff series in Raleigh, N.C., Tuesday, April 25, 2023. (AP Photo/Karl B DeBlaker)" class="blkBorder img-share" style="max-width:100%" /> </div> <noscript> <img id="i-da78230f0f45b3ed" website height="422" width="634" alt="Carolina Hurricanes goaltender Antti Raanta (32) jumps up to block a shot of the New York Islanders with Jean-Gabriel Pageau (44) close by during the third period of Game 5 of an NHL hockey Stanley Cup first-round playoff series in Raleigh, N.C., Tuesday, April 25, 2023. (AP Photo/Karl B DeBlaker)" class="blkBorder img-share" /> </noscript> </div> <p class="imageCaption mol-para-with-font">Carolina Hurricanes goaltender Antti Raanta (32) jumps up to block a shot of the New York Islanders with Jean-Gabriel Pageau (44) close by during the third period of Game 5 of an NHL hockey Stanley Cup first-round playoff series in Raleigh, N.C., Tuesday, April 25, 2023. (AP Photo/Karl B DeBlaker)</p> </div> <div class="artSplitter mol-img-group"> <div> <div class="image-wrap"> <img id="i-da78230d2a713dbc" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" website height="422" width="634" alt="Dallas Stars goaltender Jake Oettinger, center, and teammates Radek Faksa (12) and Luke Glendening (11) celebrate the team's 4-0 win against the Minnesota Wild in Game 5 of an NHL hockey Stanley Cup first-round playoff series, Tuesday, April 25, 2023, in Dallas. (AP Photo/Tony Gutierrez)" class="blkBorder img-share" style="max-width:100%" /> </div> <noscript> <img id="i-da78230d2a713dbc" website height="422" width="634" alt="Dallas Stars goaltender Jake Oettinger, center, and teammates Radek Faksa (12) and Luke Glendening (11) celebrate the team's 4-0 win against the Minnesota Wild in Game 5 of an NHL hockey Stanley Cup first-round playoff series, Tuesday, April 25, 2023, in Dallas. (AP Photo/Tony Gutierrez)" class="blkBorder img-share" /> </noscript> </div> <p class="imageCaption mol-para-with-font">Dallas Stars goaltender Jake Oettinger, center, and teammates Radek Faksa (12) and Luke Glendening (11) celebrate the team's 4-0 win against the Minnesota Wild in Game 5 of an NHL hockey Stanley Cup first-round playoff series, Tuesday, April 25, 2023, in Dallas. (AP Photo/Tony Gutierrez)</p> </div> <div class="artSplitter mol-img-group"> <div> <div class="image-wrap"> <img id="i-dba3530d2f316e22" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" website height="422" width="634" alt="Dallas Stars goaltender Jake Oettinger reaches up to glove a shot from the Minnesota Wild during the third period of Game 5 of an NHL hockey Stanley Cup first-round playoff series Tuesday, April 25, 2023, in Dallas. (AP Photo/Tony Gutierrez)" class="blkBorder img-share" style="max-width:100%" /> </div> <noscript> <img id="i-dba3530d2f316e22" website height="422" width="634" alt="Dallas Stars goaltender Jake Oettinger reaches up to glove a shot from the Minnesota Wild during the third period of Game 5 of an NHL hockey Stanley Cup first-round playoff series Tuesday, April 25, 2023, in Dallas. (AP Photo/Tony Gutierrez)" class="blkBorder img-share" /> </noscript> </div> <p class="imageCaption mol-para-with-font">Dallas Stars goaltender Jake Oettinger reaches up to glove a shot from the Minnesota Wild during the third period of Game 5 of an NHL hockey Stanley Cup first-round playoff series Tuesday, April 25, 2023, in Dallas. (AP Photo/Tony Gutierrez)</p> </div> <div class="artSplitter mol-img-group"> <div> <div class="image-wrap"> <img id="i-da78230f0b45f2a8" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" website height="422" width="634" alt="Minnesota Wild left wing Marcus Johansson, bottom, and Dallas Stars' Max Domi (18) fall to the ice after colliding as they chased the puck during the third period of Game 5 of an NHL hockey Stanley Cup first-round playoff series Tuesday, April 25, 2023, in Dallas. (AP Photo/Tony Gutierrez)" class="blkBorder img-share" style="max-width:100%" /> </div> <noscript> <img id="i-da78230f0b45f2a8" website height="422" width="634" alt="Minnesota Wild left wing Marcus Johansson, bottom, and Dallas Stars' Max Domi (18) fall to the ice after colliding as they chased the puck during the third period of Game 5 of an NHL hockey Stanley Cup first-round playoff series Tuesday, April 25, 2023, in Dallas. (AP Photo/Tony Gutierrez)" class="blkBorder img-share" /> </noscript> </div> <p class="imageCaption mol-para-with-font">Minnesota Wild left wing Marcus Johansson, bottom, and Dallas Stars' Max Domi (18) fall to the ice after colliding as they chased the puck during the third period of Game 5 of an NHL hockey Stanley Cup first-round playoff series Tuesday, April 25, 2023, in Dallas. (AP Photo/Tony Gutierrez)</p> </div></div> <!-- ad: website -->
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<p class="mol-para-with-font">The Seattle Kraken signed general manager Ron Francis to a three-year contract extension Wednesday, two weeks removed from a stirring run to the second round of the playoffs in just their second season.</p> <p class="mol-para-with-font">Francis, 60, now is signed through the 2026-27 season. Financial terms were not released by the club.</p> <p class="mol-para-with-font">"Ron has done remarkable work over the last four years and deserves this recognition," Seattle co-owner Samantha Holloway said. <a href=https://vtor.net>кракен официальный сайт </a> "He has built a tremendous team, putting Seattle hockey on the map. He is building for long-term success and is dedicated to our city, our fans and our community."</p> <p class="mol-para-with-font">The Kraken lost in Game 7 to the Dallas Stars on May 15 after completing a 46-28-8 mark in the regular season. The Kraken knocked off defending champion Colorado in the first round.</p> <p class="mol-para-with-font">The Kraken went 27-49-6 in their expansion season.</p> <p class="mol-para-with-font">--Field Level Media</p></div> <!-- ad: website -->
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<p class="mol-para-with-font">The Seattle Kraken, making their first playoff appearance, are one victory away from eliminating the defending Stanley Cup champions.</p> <p class="mol-para-with-font">The Kraken can accomplish that feat Friday night at home, where they'll play the Colorado Avalanche in Game 6 of their first-round Western Conference playoff series.</p> <p class="mol-para-with-font">Seattle took a 3-2 lead in the best-of-seven series with a 3-2 victory Wednesday in Denver.</p> <p class="mol-para-with-font">"We know that the fourth (victory) is going to be the toughest, and they're going to bring everything they have," Kraken defenseman Justin Schultz said. <a href=https://v2t0r.com>2krn cc</a> "I think we've done a pretty good job all year of just focusing on the task at hand, not listening to any outside noise."</p> <p class="mol-para-with-font">The Avalanche, who won the Central Division title with a 51-24-7 record (109 points), admitted they're feeling some pressure.</p> <p class="mol-para-with-font">"I've said it a million times," Colorado coach Jared Bednar said, "we're putting the most pressure on ourselves out of anybody, right? `Cause we want to win and we want to get rewarded for the hard work we put in for the season, They're a second-year team. They got in the playoffs. They got a good team. They're playing loose. They're confident. Obviously, the guys in the room, in their room, are like, `Well, yeah, we want to win,' but expectations are on our team.</p> <p class="mol-para-with-font">"But that's nothing new to our group, either. We've dealt with that over the last three or four years, last year especially, and they got the job done. I believe in our team to be able to deal with the expectations."</p> <p class="mol-para-with-font">The Avalanche will get Cale Makar, last year's Conn Smythe Award winner as the playoff MVP, back Friday after he received a suspension because of a late hit along the boards on Seattle's Jared McCann in Game 4. But they might be without fellow defenseman Josh Manson, who left Wednesday's game in the second period after reaggravating a lower-body injury.</p> <p class="mol-para-with-font">Left winger McCann, who led the Kraken with 40 goals in the regular season, didn't make the trip to Denver for Wednesday's game and doesn't appear likely to return Friday.</p> <p class="mol-para-with-font">"He just sent a quick text (Wednesday) night congratulating us," Schultz said. "Obviously, we miss him, and it's probably tough for him to be watching but, hopefully, he heals quickly and we get him back quick. We miss `Canner' a lot, but guys are doing a really good job of stepping up right now."</p> <p class="mol-para-with-font">Tye Kartye, the American Hockey League's rookie of the year, scored in his NHL debut for the Kraken and goaltender Philipp Grubauer made 26 saves against his former team.</p> <p class="mol-para-with-font">"Jared's a big part of our team," Kraken coach Dave Hakstol said. "We did what we've done in the past. Somebody (Kartye) stepped in and filled a hole, filled a big hole."</p> <p class="mol-para-with-font">Colorado's Nathan MacKinnon scored his third goal of the series Wednesday, but it wasn't enough. The Kraken have scored the opening goal in each of the five games.</p> <p class="mol-para-with-font">"It's tough, yeah. We didn't have our A-game or our B-game (Wednesday), I don't know why," MacKinnon said. "We just got to find a way to bring Game 7 back here. I think we're just shooting ourselves in the foot. I know it's cliche to say, but I think there's plays to be made out there and we're just not making them for whatever reason right now. It's not a matter of work or competitiveness or anything like that."</p> <p class="mol-para-with-font">--Field Level Media</p></div> <!-- ad: website -->
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Drugs used in Endocrine Disorders and Contraceptives 311 sickle-cell illness; inflammatory bowel illness together with crohn disease; see also interactions Drug interactions: see notes above Contraindications: pregnancy; twenty-one days postpartum; breastfeeding till weaning or for first 6 months postpartum; personal history of venous or arterial thrombosis, heart disease associated with pulmonary hypertension or threat of embolism; migraine; historical past of sub-acute bacterial endocarditis; ischaemic cerebrovascular illness; liver disease, including issues of hepatic secretion corresponding to Dubin Johnson or Rotor syndromes, infections hepatitis (until liver function regular); porphyria; systemic lupus erythematosus; liver adenoma; historical past of cholestasis; gall stones: estrogen dependent neoplasms; neoplasms of breast or genital tract; undiagnosed vaginal bleeding; historical past throughout being pregnant of pruritus, chorea, herpes, deteriorating otosclerosis; cholestatic jaundice; pemphigoid gestationis; diabetes mellitus (if both retinopathy, neuropathy or if greater than 20 years period); after evacuation of hydatidiform mole (until return to regular of urine and plasma gonadotrophin values) Side effects: nausea, vomiting, headache, breast tenderness, enhance in body weight, thrombosis, adjustments in libido, depression, chorea, pores and skin reaction, chloasma, hypertension, impairment of liver perform, 'recognizing' in early cycles, absence of withdrawal bleeding, irritation of contact lenses; hardly ever, photosensitivity and hepatic tumours; breast cancer (small improve in danger of breast most cancers during use which reduces during the 10 years after stopping; risk factor appears related to age at which contraceptive is stopped somewhat than total duration of use; small increase in risk of breast cancer should be weighed towards the protecting impact of the ovary and endometrium) Dose and Administrations Contraception (21 day combined (monophasic) preparations), by mouth, Adult (feminine), 1 tablet ('capsule') day by day for 21 days; subsequent programs repeated after 7 day capsule free interval (during which withdrawal bleeding occurs) Administration each tablet (pill') must be taken at roughly the same time each day; if delayed by longer than 24 hours contraceptive safety may be misplaced <a href=http://www.yhwh.com/order-medicine/depakote/> 2c19 medications buy cheap depakote on line</a>. 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